導讀：最近梅奧診所與伊利諾伊大學的地質(zhì)學家合作發(fā)現(xiàn)，草酸鈣腎結(jié)石是在不斷溶解和再生長中形成的。這為未來有機會不通過手術(shù)就治療腎結(jié)石提供了靈感。接下來，讓我們看看梅奧診所官方新聞是如何報道這場跨學科研究的。
Can geology upend decades of medical wisdom about kidney stones?
地質(zhì)學顛覆了醫(yī)生幾十年來對腎結(jié)石的認識？
Mayo Clinic Medical Science Blog; September 25, 2018
Like stones formed in nature, kidney stones show signs of being partially dissolved and remade. Implication: there may be a way to remove kidney stones without surgery or passing them in urine.
就像自然界中的石頭一樣，腎結(jié)石也會部分溶解并再生長。這意味著，也許可以不進行手術(shù)或者不通過排尿就可以清除腎結(jié)石。
An unlikely collaboration between a geologist at the University of Illinois Urbana-Champaign and researchers at Mayo Clinic has overturned physicians’ long-held assumptions about the nature of kidney stones. Physicians believed kidney stones could not be dissolved, and so did not pursue developing a non-surgical treatment.
過去，醫(yī)生們都認為腎結(jié)石不能溶解，所以沒有研究非手術(shù)的治療方式。但伊利諾伊大學厄巴納-香檳分校的地質(zhì)學家與梅奧診所的研究人員的意外合作卻獲得了與上述觀點完全相反的發(fā)現(xiàn)。
With the publication of this study Scientific Reports, the race has now begun to identify the stone-dissolving process in the kidney so that physicians can develop a treatment.
該發(fā)現(xiàn)發(fā)表在《科學報告》（Scientific Reports）中，研究人員已開始研究在腎臟中溶解結(jié)石的過程，這有助于開發(fā)新的治療方法。
Bruce Fouke, Ph.D. , is a geologist who studies microbes in rock formations from ancient coral reefs to Roman aqueducts to hot springs. After giving a talk at Mayo Clinic, he was recruited by John Lieske, M.D., to look at patients’ kidney stones.
Bruce Fouke博士是一名地質(zhì)學家，對各種地方形成的石頭都做過微生物研究，比如古珊瑚礁里的石頭，羅馬水道里的石頭，還有溫泉里的石頭。Bruce Fouke博士在梅奧診所發(fā)表演講后，收到了醫(yī)學博士John Lieske的邀請，來研究患者的腎結(jié)石。
When asked what he thought of working with his Mayo-based colleagues, Dr. Fouke said, “In my career I don’t know that I’ve had a more exciting, inspiring, and insightful collaboration.”
關(guān)于這次與梅奧診所的合作，F(xiàn)ouke博士說：“這是我職業(yè)生涯中最令我興奮、最具啟發(fā)性也是意義最深遠的一次合作！”
Dr. Fouke applied his geology expertise to examine stones extracted from Mayo Clinic patients. His group then performed an extensive analysis of very thin layers of the kidney stones with several high-powered super-resolution microscopy techniques.
Fouke博士運用專業(yè)的地質(zhì)知識對從梅奧診所患者身上取出的結(jié)石進行了研究。他的小組利用多種高性能的超分辨率顯微鏡技術(shù)對超薄的腎結(jié)石切片進行了全面分析。
Cross section of a kidney stone. Image provided by UIUC.
腎結(jié)石的橫截面。圖片來源：伊利諾伊大學厄巴納-香檳分校。
By carefully examining the composition of the kidney stones, they were able to show that a kidney stone does not continuously grow like previously thought. Instead, the minerals of the stone show evidence of dissolving and reforming.
仔細研究腎結(jié)石的成分后他們發(fā)現(xiàn)，腎結(jié)石其實不是之前認為的那樣在不斷生長，而是處于不斷溶解和再形成的循環(huán)之中。
Different layers are formed by the process, similar to the stratification of stones and fossils that Dr. Fouke had previously studied. In fact, the layers appear to capture information about what is happening in the kidney in the same way that fossils from different time periods are trapped in different layers of rocks. In the future, these layers of information could be used to find what has happened in an individual patient’s kidney, giving clues and context for physicians to administer personalized medicine.
這個過程中，結(jié)石便形成了不同的層次，這類似于Fouke博士研究的巖石分層與化石的問題，通過化石可以推斷其所在巖石層的狀況，這些結(jié)石的分層也可反映腎臟內(nèi)部的變化信息。將來利用這些分層信息可以研究患者的腎臟發(fā)展狀況，為醫(yī)生提供個性化治療的線索和背景。
Imageprovided by UIUC.
圖片來源：伊利諾伊大學厄巴納-香檳分校。
聯(lián)系客服
