九色国产,午夜在线视频,新黄色网址,九九色综合,天天做夜夜做久久做狠狠,天天躁夜夜躁狠狠躁2021a,久久不卡一区二区三区

研究人員發(fā)現(xiàn)了一種新方法能夠創(chuàng)建豬和人類(lèi)細(xì)胞的擴(kuò)增潛能干細(xì)胞（EPSC），這些EPSC具有胚胎中最早細(xì)胞特征，可發(fā)育成任何類(lèi)型的細(xì)胞。這項(xiàng)研究發(fā)表在Nature Cell Biology雜志上。

家豬與人類(lèi)遺傳和解剖學(xué)具有高度相似性，具有巨大的生物醫(yī)學(xué)研究潛力，通過(guò)遺傳修飾豬干細(xì)胞不僅有益于動(dòng)物健康也可以更好的掌控食物生產(chǎn)。最近研究通過(guò)抑制導(dǎo)致胚胎分化的關(guān)鍵分子途徑，從單個(gè)卵裂球中獲得了小鼠擴(kuò)增的潛在干細(xì)胞。胚胎干細(xì)胞豐富了卵裂球的分子特征，對(duì)所有胚胎和胚胎外細(xì)胞系都具有發(fā)育潛能。該項(xiàng)研究通過(guò)應(yīng)用以上技術(shù)方法報(bào)道了豬胚胎干細(xì)胞的來(lái)源，其表達(dá)關(guān)鍵的多能基因，遺傳穩(wěn)定，允許基因組編輯，在嵌合體中分化為三個(gè)生殖層的衍生物，并在體外產(chǎn)生原始生殖細(xì)胞樣細(xì)胞，這是科學(xué)家們第一次從早期豬胚胎中獲得干細(xì)胞。

因此，推測(cè)在類(lèi)似條件下人胚胎干細(xì)胞或誘導(dǎo)多能干細(xì)胞可被轉(zhuǎn)化，或體細(xì)胞可直接被重新編程，從而具有胚胎干細(xì)胞的分子和功能屬性。該研究為哺乳動(dòng)物多能干細(xì)胞的培養(yǎng)開(kāi)辟了一條新途徑，同時(shí)通過(guò)該技術(shù)獲取的胚胎干細(xì)胞為再生醫(yī)學(xué)的轉(zhuǎn)化研究提供了一個(gè)全新而特有的細(xì)胞平臺(tái)。

推薦閱讀原文：

Establishment of porcine and human expanded potential stem cells

We recently derived mouse expanded potential stem cells (EPSCs) from individual blastomeres by inhibiting the critical molecular pathways that predispose their differentiation. EPSCs had enriched molecular signatures of blastomeres and possessed developmental potency for all embryonic and extra-embryonic cell lineages. Here, we report the derivation of porcine EPSCs, which express key pluripotency genes, are genetically stable, permit genome editing, differentiate to derivatives of the three germ layers in chimeras and produce primordial germ cell-like cells in vitro. Under similar conditions, human embryonic stem cells and induced pluripotent stem cells can be converted, or somatic cells directly reprogrammed, to EPSCs that display the molecular and functional attributes reminiscent of porcine EPSCs. Importantly, trophoblast stem-cell-like cells can be generated from both human and porcine EPSCs. Our pathway-inhibition paradigm thus opens an avenue for generating mammalian pluripotent stem cells, and EPSCs present a unique cellular platform for translational research in biotechnology and regenerative medicine.